Thymidylate Synthase (5-FU Resistance Marker)(rTYMS/1884), CF405S conjugate, 0.1mg/mL [26628-22-8]

Biotium

Thymidylate Synthase (5-FU Resistance Marker)(rTYMS/1884), CF405S conjugate, 0.1mg/mL

9

Flow Cytometry, ImmunoFluorescence

Research Use Only

Monoclonal

rTYMS/1884

0.1 mg/ml

Other Conjugate

TYMS

thymidylate synthetase

HST422; thymidylate synthase; TMS; TS; TSase

Mouse

IgG1

Thymidylate synthase

Recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS) (EC 2. 1. 1. 45). It converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5, 10-methylenetetrahydrofolate. Expression of TS protein has been reported to associate with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

Human

2°C to 8°C

12352203