![Thymidylate Synthase(TS106 + TMS715), CF405S conjugate, 0.1mg/mL [26628-22-8] Thymidylate Synthase(TS106 + TMS715), CF405S conjugate, 0.1mg/mL [26628-22-8]](https://biotium.com/wp-content/uploads/2016/12/BNUB0716-0-1.jpg)
Thymidylate Synthase(TS106 + TMS715), CF405S conjugate, 0.1mg/mL [26628-22-8]
BNC040716
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Human, Mouse
TargetTYMS
Overview
- SupplierBiotium
- Product NameThymidylate Synthase(TS106 + TMS715), CF405S conjugate, 0.1mg/mL
- Delivery Days Customer9
- ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDTS106 TMS715
- Concentration0.1 mg/ml
- ConjugateOther Conjugate
- Gene ID7298
- Target nameTYMS
- Target descriptionthymidylate synthetase
- Target synonymsHST422; thymidylate synthase; TMS; TS; TSase
- HostMouse
- IsotypeIgG
- Protein IDP04818
- Protein NameThymidylate synthase
- Scientific DescriptionThis antibody recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- SourceAnimal
- ReactivityBovine, Human, Mouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203