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TIAM1 Polyclonal Antibody

Research Use Only
RD265751A
Reddot Biotech
ApplicationsImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetTIAM1
Price on request
Packing Size
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Overview

  • Supplier
    Reddot Biotech
  • Product Name
    TIAM1 Polyclonal Antibody
  • Delivery Days Customer
    5
  • Applications
    ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID7074
  • Target name
    TIAM1
  • Target description
    TIAM Rac1 associated GEF 1
  • Target synonyms
    human T-lymphoma invasion and metastasis inducing TIAM1 protein; rho guanine nucleotide exchange factor TIAM1; T cell lymphoma invasion and metastasis 1; TIAM-1; T-lymphoma invasion and metastasis-inducing protein 1
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. This gene thus plays an important role in cell invasion, metastasis, and carcinogenesis. In addition to RAC1, the encoded protein activates additional Rho-like GTPases such as CDC42, RAC2, RAC3 and RHOA. This gene encodes multiple protein isoforms that experience a diverse array of intramolecular, protein-protein, and phosphorylation interactions as well as phosphoinositide binding. Both the longer and shorter isoforms have C-terminal Dbl homology (DH) and pleckstrin homology (PH) domains while only the longer isoforms of this gene have the N-terminal myristoylation site and the downstream N-terminal PH domain, ras-binding domain (RBD), and PSD-95/DlgA/ZO-1 (PDZ) domain.
  • Reactivity
    Human
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203