TIAM1 Polyclonal Antibody
RD265751A
ApplicationsImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetTIAM1
Overview
- SupplierReddot Biotech
- Product NameTIAM1 Polyclonal Antibody
- Delivery Days Customer5
- ApplicationsImmunoHistoChemistry
- CertificationResearch Use Only
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID7074
- Target nameTIAM1
- Target descriptionTIAM Rac1 associated GEF 1
- Target synonymshuman T-lymphoma invasion and metastasis inducing TIAM1 protein; rho guanine nucleotide exchange factor TIAM1; T cell lymphoma invasion and metastasis 1; TIAM-1; T-lymphoma invasion and metastasis-inducing protein 1
- HostRabbit
- IsotypeIgG
- Scientific DescriptionThis gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. This gene thus plays an important role in cell invasion, metastasis, and carcinogenesis. In addition to RAC1, the encoded protein activates additional Rho-like GTPases such as CDC42, RAC2, RAC3 and RHOA. This gene encodes multiple protein isoforms that experience a diverse array of intramolecular, protein-protein, and phosphorylation interactions as well as phosphoinositide binding. Both the longer and shorter isoforms have C-terminal Dbl homology (DH) and pleckstrin homology (PH) domains while only the longer isoforms of this gene have the N-terminal myristoylation site and the downstream N-terminal PH domain, ras-binding domain (RBD), and PSD-95/DlgA/ZO-1 (PDZ) domain.
- ReactivityHuman
- Storage Instruction-20°C
- UNSPSC12352203