Tirapazamine

AbMole BioScience

Tirapazamine

9

27314-97-2

Chemical

Research Use Only

C7H6N4O2

178.15

Tirapazamine (TPZ，SR-4233, WIN 59075) is the first hypoxia-activated prodrug. Tirapazamine kills hypoxic cells by inducing chromosome aberrations and DNA double-strand breaks. Tirapazamine induced cell cycle arrest and apoptosis, and down-regulated HIF-1alfa, CA-IX and VEGF expression.

NC1=[N+]([O-])C2=CC=CC=C2[N+](=N1)[O-]

12352200