TLR1 Polyclonal Antibody

Reddot Biotech

TLR1 Polyclonal Antibody

5

2 mg/ml

TLR1

toll like receptor 1

CD281; rsc786; TIL; TIL. LPRS5; toll/interleukin-1 receptor-like protein; toll-like receptor 1

Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852). Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

-20°C

12352203