TLR5 Polyclonal Antibody

Reddot Biotech

TLR5 Polyclonal Antibody

5

Western Blot, ImmunoHistoChemistry

Research Use Only

1 mg/ml

Unconjugated

TLR5

toll like receptor 5

MELIOS; SLE1; SLEB1; systemic lupus erythematosus susceptibility 1; TIL3; toll/interleukin-1 receptor-like protein 3; toll-like receptor 5

Rabbit

IgG

This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.

Human

-20°C

12352203