TLR7 agonist 27

MedChem Express

TLR7 agonist 27

9

Research Use Only

C47H64N10O11

945.07

TLR7 agonist 27 (compound 24) is a potent TLR7 agonist with an EC50 of 238.1 nM. TLR7 agonist 27 shows weak agonistic activity against NOD2 (nucleotide-binding oligomerization domain 2) (EC50 of 6.2 microM). TLR7 agonist 27 is a potent immunostimulant, and can be used as a vaccine adjuvant and/or immunotherapeutic[1].

COC1=C(O)C=CC(/C=C/C(NCC(N[C@H](C(N[C@@H](C(OCC)=O)CCC(NCCCCCCNC(C(C=C2)=CC=C2CN3C4=NC(OCCCC)=NC(N)=C4N=C3O)=O)=O)=O)C(C)C)=O)=O)=C1

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