TLR7/8 antagonist 1

MedChem Express

TLR7/8 antagonist 1

10

Research Use Only

C24H27N5O2

417.5

TLR7/8 Antagonist 1 (Compound 16c) is the potent antagonist of TLR7/8 with IC50s of 3.91 and 2.19 microM, respectively. TLR7/8 Antagonist 1 is an imidazoquinoline derivative compound. Toll-like receptors (TLRs) 7 and 8 are key targets in the development of immunomodulatory drugs for researching infectious disease, cancer, and autoimmune disorders.

COC(C1=CC2=NC(N)=C3N=C(N(C3=C2C=C1)CC4=CC=C(CN)C=C4)CC(C)C)=O

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