TM-233

MedChem Express

TM-233

9

Research Use Only

C25H20O4

384.42

TM-233 is an inhibitor of the JAK/STAT and NF-kappaB signaling pathways, exhibiting significant antitumor activity. TM-233 reduces the expression of the anti-apoptotic protein Mcl-1 by inhibiting the phosphorylation of JAK2 and STAT3, and regulates its transcription by directly binding to the Mcl-1 gene promoter. Additionally, TM-233 prevents the translocation of NF-kappaB from the cytoplasm to the nucleus by inhibiting its DNA-binding activity, thereby reducing nuclear NF-kappaB expression. TM-233 shows potential in overcoming Bortezomib (HY-10227) resistance and can be applied in research related to multiple myeloma[1].

CC(OC(C1=CC=C(C=C1)OC(C)=O)C2=C3C=CC=CC3=CC4=CC=CC=C24)=O

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