TM5441 (sodium)

MedChem Express

TM5441 (sodium)

14

Research Use Only

C21H16ClN2NaO6

450.80

TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1) , has IC 50 values between 13.9 and 51.1 microM. TM5441 induces intrinsic apoptosis in several human cancer cell lines. TM5441 attenuates Nomega-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence [1] [2] .

ClC1=CC=C(NC(COCC(NC2=CC=CC(C3=COC=C3)=C2)=O)=O)C(C(O[Na])=O)=C1

12352200