TMEM173 Antibody, HRP conjugated

Cusabio

TMEM173 Antibody, HRP conjugated

20

ELISA

Research Use Only

Polyclonal

HRP

STING1

stimulator of interferon response cGAMP interactor 1

ERIS, MITA, MPYS, NET23, SAVI, STING, STING-beta, TMEM173, hMITA, hSTING, stimulator of interferon genes protein, N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner, endoplasmic reticulum IFN stimulator, endoplasmic reticulum interferon stimulator, mitochondrial mediator of IRF3 activation, stimulator of interferon protein, stimulator of interferon response cGAMP interactor-deltaC, stimulator of interferon response cGAMP interactor-deltaN, sting 1, transmembrane protein 173

Rabbit

IgG

Stimulator of interferon genes protein

Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Essential for the induction of IFN-beta in response to human herpes simplex virus 1 (HHV-1) infection. Exhibits 2,3 phosphodiester linkage-specific ligand recognition. Can bind both 2-3 linked cGAMP and 3-3 linked cGAMP but is preferentially activated by 2-3 linked cGAMP (PubMed:26300263).

Human

-20°C or -80°C

41116161