TMEPAI Antibody / PMEPA1
![Research Use Only](static/images/certificates/ruo.jpg)
ORB606833
Overview
- SupplierBiorbyt
- Product NameTMEPAI Antibody / PMEPA1
- Delivery Days Customer16
- ApplicationsImmunoHistoChemistry
- Applications SupplierImmunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT (1) IHC-P
- CertificationResearch Use Only
- Clone IDPMEPA1/2697
- IsotypeIgG
- Scientific DescriptionPMEPA1 (prostate transmembrane protein, androgen induced 1), or TMEPAI (Transmembrane prostate androgen induced protein) is a 287 amino acid single-pass membrane protein that contains WW-binding motifs and localizes to the cell membrane. Expressed at high levels in prostate, kidney and ovary, PMEPA1/TMEPAI interacts with NEDD4 and may play a role in regulating AR (androgen receptor) levels, specifically in prostate cells. Down regulation of TMEPAI is observed in prostate tumors, suggesting that TMEPAI may exhibit activity as a tumor suppressor. Overexpression of this protein may play a role in multiple types of cancer.
- UNSPSC12352203