TMI-1

MedChem Express

TMI-1 [287403-39-8]

10

287403-39-8

Research Use Only

99.59

C17H22N2O5S2

398.50

TMI-1 (WAY-171318) inhibits TNF converting enzyme (TACE) ( IC 50 of 8.4 nM), ADAM-TS-4 , ADAM-17 and various MMPs with oral activity. TMI-1 significantly suppresses the secretion of TNF-alpha , alleviating collagen-induced arthritis in mice. TMI-1 inhibits cancer cell proliferation, induces apoptosis through a caspase-dependent pathway. TMI-1 also reverses TRPV1 upregulation and lowers the levels of inflammatory factors ( TNF-alpha , IL-1beta , IL-6 ) in nerve cells, protecting against paclitaxel-induced neurotoxicity. TMI-1 leads to changes in pro-atherogenic lipoprotein profiles, but does not affect the progression of early lesions [1] [2] [3] [4] .

O=C([C@@H]1N(S(=O)(C2=CC=C(OCC#CC)C=C2)=O)CCSC1(C)C)NO

-20°C

12352200