TMX-4153

MedChem Express

TMX-4153

10

Research Use Only

98.96

C59H67ClN10O6S

1079.74

TMX-4153 is a bivalent degrader. TMX-4153 rapidly and selectively degrades endogenous PIP4K2C by recruiting the von Hippel-Lindau (VHL) E3 ligase complex, with a K D value of 42 nM. TMX-4153 can be used to synthesize PROTAC [1] .

ClC1=CN=C(N=C1C2=CC=CC(C3=CC=CC=C3)=C2)NC4=CC(N(C5=O)CCC5(CC6)CCN6C(CCCCCC(N[C@H](C(N7[C@H](C(N[C@@H](C)C8=CC=C(C9=C(C)N=CS9)C=C8)=O)C[C@@H](O)C7)=O)C(C)(C)C)=O)=O)=CN=C4

-20°C,2°C to 8°C

12352200