Western Blot analysis of Recombinant Human TNF a Protein using TNF alpha Monoclonal Antibody at dilution of 1:2000.
Western Blot analysis of Recombinant Human TNF a Protein using TNF alpha Monoclonal Antibody at dilution of 1:2000.
TNF alpha Monoclonal Antibody
E-AB-22159
Product group Antibodies
Overview
- SupplierElabscience
- Product NameTNF alpha Monoclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionTNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
- UNSPSC12352203