![TNF alpha(J2D10), CF405S conjugate, 0.1mg/mL [26628-22-8] TNF alpha(J2D10), CF405S conjugate, 0.1mg/mL [26628-22-8]](https://biotium.com/wp-content/uploads/2016/12/BNUB0994-0-1.jpg)
TNF alpha(J2D10), CF405S conjugate, 0.1mg/mL [26628-22-8]
BNC040994
ApplicationsELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Human, Mouse
TargetTNF
Overview
- SupplierBiotium
- Product NameTNF alpha(J2D10), CF405S conjugate, 0.1mg/mL
- Delivery Days Customer9
- ApplicationsELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDJ2D10
- Concentration0.1 mg/ml
- ConjugateOther Conjugate
- Gene ID7124
- Target nameTNF
- Target descriptiontumor necrosis factor
- Target synonymsAPC1 protein; DIF; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNF-alpha; TNFSF2; TNLG1F; tumor necrosis factor; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha
- HostMouse
- IsotypeIgG1
- Protein IDP01375
- Protein NameTumor necrosis factor
- Scientific DescriptionThis antibody neutralises HurTNFamediated cytotoxicity of L929 cells and inhibits tumour growth in mice. It protects mice against toxicity of HurTNFa. Tumor Necrosis Factor Alpha (TNF alpha) is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF alpha exists as a multimer of two, three, or five non-covalently linked units, but shows a single 17 kDa band following SDS PAGE under non-reducing conditions. TNF alpha is closely related to the 25 kDa protein Tumor Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular actions. TNF alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- SourceAnimal
- ReactivityBovine, Human, Mouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203