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Western blot analysis of extracts from RAW264.7 cells, using TNAP3 antibody.
Western blot analysis of extracts from RAW264.7 cells, using TNAP3 antibody.
Western blot analysis of extracts from RAW264.7 cells, using TNAP3 antibody.

TNFAIP3 Antibody

Research Use Only
CSB-PA257212
Cusabio
ApplicationsImmunoFluorescence, Western Blot, ELISA
Product group Antibodies
ReactivityHuman
TargetTNFAIP3
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Overview

  • Supplier
    Cusabio
  • Product Name
    TNFAIP3 Antibody
  • Delivery Days Customer
    20
  • Applications
    ImmunoFluorescence, Western Blot, ELISA
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID7128
  • Target name
    TNFAIP3
  • Target description
    TNF alpha induced protein 3
  • Target synonyms
    A20; AISBL; OTU domain-containing protein 7C; OTUD7C; putative DNA-binding protein A20; TNFA1P2; tumor necrosis factor alpha-induced protein 3; tumor necrosis factor inducible protein A20; tumor necrosis factor, alpha induced protein 3; zinc finger protein A20
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP21580
  • Protein Name
    Tumor necrosis factor alpha-induced protein 3
  • Scientific Description
    Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates Lys-63-polyubiquitin chains on RIPK1 and catalyzes the formation of Lys-48-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on Lys-63-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates Lys-63-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate Lys-11-, Lys-48- and Lys-63 polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of proinflammatory cytokines and IFN beta in LPS-tolerized macrophages. Opipari A.W. Jr., J. Biol. Chem. 265:14705-14708(1990). Mungall A.J., Nature 425:805-811(2003). Eliopoulos A.G., J. Virol. 73:1023-1035(1999).
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203