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ProductsBack/TNFRSF11B Antibody

TNFRSF11B Antibody

Research Use Only
CSB-PA119257
Cusabio
ApplicationsWestern Blot, ELISA
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse
Price on request
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More than 130 suppliers
ISO certified
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Overview

  • Supplier
    Cusabio
  • Product Name
    TNFRSF11B Antibody
  • Delivery Days Customer
    20
  • Applications
    Western Blot, ELISA
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. Simonet W.S., Cell 89:309-319(1997). Yasuda H., Endocrinology 139:1329-1337(1998). Morinaga T., Eur. J. Biochem. 254:685-691(1998).
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203