TO3-3PEG-Biotin Fluorophore

Applied Biological Materials

TO3-3PEG-Biotin Fluorophore

9

Labeling/Conjugation

Research Use Only

RNA Mango technology is based on the specific binding of the RNA Mango Aptamer and a Thizole Orange (TO) bi-functional dye. The main features of this technology is the tight binding between the dye and aptamer (KD ~ 3nM) , and the strong ~1000X enhancement of the dyes fluorescence when bound to the Mango apatmer (Fluorescent enhancement FE=1,100).The TO dye has a number of other desirable properties including: -small size -lack of toxicity -plasma and nuclear membrane permeability -short intracellular half-life -the accessibility of a broad wavelength range simply via substitutions and alterations to the TO structure -TO1 and TO3 dyes can be used in a 2-color reporter assay system using both the RNA Mango and RNA Peach Aptamer systems (Kong et. al. 2021) Learn more about the RNA Mango technology here.

-20°C

41116134