Tolafentrine

MedChem Express

Tolafentrine [139308-65-9]

5

139308-65-9

Research Use Only

C28H31N3O4S

505.63

Tolafentrine, a dual-selective phosphodiesterase 3/4 (PDE3/4) inhibitor, has been shown to have significant acute and chronic effects in a unilateral diacetamide-induced rat pulmonary hypertension model. Experiments show that long-term administration can significantly alleviate all unilateral bisacetamide-induced hemodynamic and gas exchange abnormalities, reduce right ventricular hypertrophy, and normalize pulmonary vascular remodeling changes [1] .

[H][C@@]12CN(CC[C@@]1(N=C(C3=C2C=C(C(OC)=C3)OC)C4=CC=C(C=C4)NS(C5=CC=C(C=C5)C)(=O)=O)[H])C

12352200