Tolcapone-d4

MedChem Express

Tolcapone-d4 [1246816-93-2]

10

1246816-93-2

Research Use Only

99.13

C14H7D4NO5

277.27

Tolcapone-d 4 is the deuterium labeled Tolcapone. Tolcapone (Ro 40-7592) is a selective, orally active and powerful mixed (peripheral and central) COMT inhibitor with an IC50 of 773 nM in the liver[1]. Tolcapone is also a potent inhibitor of alpha-syn and Abeta42 oligomerization and fibrillogenesis[2]. Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in neuroblastoma[3].

O=C(C1=C([2H])C([2H])=C(C([2H])=C1[2H])C)C2=CC([N+]([O-])=O)=C(C(O)=C2)O

-20°C,2°C to 8°C

12352200