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ProductsBack/TOP1MT Antibody / Topoisomerase I mitochondrial

TOP1MT Antibody / Topoisomerase I mitochondrial

Research Use Only
ORB639591
Biorbyt
ApplicationsImmunoHistoChemistry
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Product group Antibodies
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Overview

  • Supplier
    Biorbyt
  • Product Name
    TOP1MT Antibody / Topoisomerase I mitochondrial
  • Delivery Days Customer
    16
  • Applications
    ImmunoHistoChemistry
  • Applications Supplier
    Immunohistochemistry (FFPE): 1-2ug/ml IHC-P
  • Certification
    Research Use Only
  • Clone ID
    TOP1MT/568
  • Isotype
    IgG
  • Scientific Description
    DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.
  • UNSPSC
    12352203