Bio-Connect

TOP2A Polyclonal Antibody

RD266822A
Reddot Biotech
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman
TargetTOP2A
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Overview

  • Supplier
    Reddot Biotech
  • Product Name
    TOP2A Polyclonal Antibody
  • Delivery Days Customer
    5
  • Applications
    Western Blot
  • Certification
    Research Use Only
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID7153
  • Target name
    TOP2A
  • Target description
    DNA topoisomerase II alpha
  • Target synonyms
    DNA gyrase; DNA topoisomerase (ATP-hydrolyzing); DNA topoisomerase 2-alpha; DNA topoisomerase II, 170 kD; DNA topoisomerase II, alpha isozyme; TOP2; TOP2alpha; TOPIIA; topoisomerase (DNA) II alpha 170kDa; TP2A
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.
  • Reactivity
    Human
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203