TOPOI/PARP-1-IN-2

MedChem Express

TOPOI/PARP-1-IN-2

9

Research Use Only

C16H11ClN4O2S

358.80

TOPOI/PARP-1-IN-2 (compound 6c) is a dual PARP-1 and topoisomerase 1 (TOPO-1) inhibitor with IC50s of 32.2 nM and 46.2 nM, respectively. TOPOI/PARP-1-IN-2 shows a selectivity for PARP-1 over PARP-2. TOPOI/PARP-1-IN-2 disrupts the cell cycle at the S phase and induces apoptosis in NCI-60 cancer cell lines[1].

S=C(N(NC(C1=C2C=CC=C1)=O)C2=O)N/N=C/C3=CC=CC=C3Cl

12352200