TP53INP1 Antibody

Cusabio

TP53INP1 Antibody

20

ImmunoFluorescence, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

TP53INP1

tumor protein p53 inducible nuclear protein 1

p53-dependent damage-inducible nuclear protein 1; p53DINP1; p53-inducible p53DINP1; SIP; stress-induced protein; Teap; TP53DINP1; TP53INP1A; TP53INP1B; tumor protein p53-inducible nuclear protein 1

Rabbit

IgG

Tumor protein p53-inducible nuclear protein 1

Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on \Ser-46\ and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.

Human

-20°C or -80°C

12352203