Western Blot analysis of Human fetal liver tissue, 293T and 231 cell using TP53INP1 Polyclonal Antibody at dilution of 1:200
Western Blot analysis of Human fetal liver tissue, 293T and 231 cell using TP53INP1 Polyclonal Antibody at dilution of 1:200
TP53INP1 Polyclonal Antibody
E-AB-13485
Product group Antibodies
Overview
- SupplierElabscience
- Product NameTP53INP1 Polyclonal Antibody
- Delivery Days Customer12
- Applications SupplierELISA WB IHC
- CertificationResearch Use Only
- Concentration0.5mg/ml
- Scientific DescriptionTP53INP1 (tumor protein p53-inducible nuclear protein 1), also known as p53DINP1, SIP or Teap, is a 240 amino acid protein that localizes to nuclear bodies and exists as two alternatively spliced isoforms, designated p53DINP1a and p53DINP1b. Expressed ubiquitously with higher expression in testis, pancreas and spleen tissue, TP53INP1 functions in response to double-stranded DNA breaks and regulates p53-mediated apoptosis, specifically by phosphorylating human p53 at Ser 46, an event that leads to cell death. Additionally, TP53INP1 is thought to interact with p73 and may be involved in the regulation of p73-controlled cell cycle progression. TP53INP1 expression is downregulated in pancreatic ductal adenocarcinomas, suggesting that, via its ability to induce cell death, TP53INP1 plays a role in tumor suppression.
- UNSPSC12352203