
Western Blot Positive WB detected in: PC3 whole cell lysate All lanes: TP63 antibody at 2.1microg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 66, 63, 52, 56, 45, 58, 47, 68, 57, 77 KDa Observed band size: 77 KDa
TP63 Recombinant Monoclonal Antibody
CSB-RA887971A0HU
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetTP63
Overview
- SupplierCusabio
- Product NameTP63 Recombinant Monoclonal Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID4B3
- ConjugateUnconjugated
- Gene ID8626
- Target nameTP63
- Target descriptiontumor protein p63
- Target synonymsAIS; amplified in squamous cell carcinoma; B(p51A); B(p51B); chronic ulcerative stomatitis protein; EEC3; keratinocyte transcription factor KET; KET; LMS; NBP; OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4; TP53CP; TP53L; TP73L; transformation-related protein 63; tumor protein 63; tumor protein p53-competing protein
- IsotypeIgG
- Protein IDQ9H3D4
- Protein NameTumor protein 63
- Scientific DescriptionActs as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203