TPB15
HY-147670
Molecular Weight453.11
Product group Chemicals
Overview
- SupplierMedChem Express
- Product NameTPB15
- Delivery Days Customer10
- CertificationResearch Use Only
- Molecular FormulaC18H9Cl4N5O
- Molecular Weight453.11
- Scientific DescriptionTPB15 is an orally active and potent Hh (Hedgehog) signaling inhibitor. TPB15 markedly induces cell cycle arrest and apoptosis in MDA-MB-468 cells. TPB15 blocks Smo (Smoothened) translocation into the cilia and reduced Smo protein and mRNA expression. TPB15 inhibits the expression of the downstream regulatory factor glioma-associated oncogene 1 ( Gli1 ). TPB15 shows good anti-tumor activity with low toxicity [1] .
- SMILESO=C(C1=C(N=C(C=C1)Cl)Cl)NC2=CC(C3=NN=C4C(Cl)=CC=CN43)=C(C=C2)Cl
- UNSPSC12352200