Bio-Connect

TPB15

HY-147670
MedChem Express
Molecular Weight453.11
Product group Chemicals
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    MedChem Express
  • Product Name
    TPB15
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Molecular Formula
    C18H9Cl4N5O
  • Molecular Weight
    453.11
  • Scientific Description
    TPB15 is an orally active and potent Hh (Hedgehog) signaling inhibitor. TPB15 markedly induces cell cycle arrest and apoptosis in MDA-MB-468 cells. TPB15 blocks Smo (Smoothened) translocation into the cilia and reduced Smo protein and mRNA expression. TPB15 inhibits the expression of the downstream regulatory factor glioma-associated oncogene 1 ( Gli1 ). TPB15 shows good anti-tumor activity with low toxicity [1] .
  • SMILES
    O=C(C1=C(N=C(C=C1)Cl)Cl)NC2=CC(C3=NN=C4C(Cl)=CC=CN43)=C(C=C2)Cl
  • UNSPSC
    12352200