TPMT Polyclonal Antibody
RD80261A
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman
TargetTPMT
Overview
- SupplierReddot Biotech
- Product NameTPMT Polyclonal Antibody
- Delivery Days Customer5
- ApplicationsWestern Blot
- CertificationResearch Use Only
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID7172
- Target nameTPMT
- Target descriptionthiopurine S-methyltransferase
- Target synonymsS-adenosyl-L-methionine:thiopurine S-methyltransferase; thiopurine S-methyltransferase; TPMTD
- HostRabbit
- IsotypeIgG
- Scientific DescriptionThis gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.
- ReactivityHuman
- Storage Instruction-20°C
- UNSPSC12352203