TPMT Polyclonal Antibody

Reddot Biotech

TPMT Polyclonal Antibody

5

1 mg/ml

TPMT

thiopurine S-methyltransferase

S-adenosyl-L-methionine:thiopurine S-methyltransferase; thiopurine S-methyltransferase; TPMTD

This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.

-20°C

12352203