trans-Indole-3-acrylic acid [29953-71-7]

AdipoGen Life Sciences

trans-Indole-3-acrylic acid

10

29953-71-7

Research Use Only

>98%

Warning

C11H9NO2

187.2

Chemical. CAS: 29953-71-7. Formula: C11H9NO2. MW: 187.2. Synthetic. Inflammation suppressor. Tryptophan metabolite produced by human microbiota (intestinal commensale Peptostreptococcus sp). Involved in keeping the intestinal barrier intact and works as anti-inflammatory molecule. Patients with Inflammatory bowel Disease (IBD) have an altered microbiota, with less Peptostreptococcus sp., and therefore reduced production of trans-indole-3-acrylic acid. Chromophoric L-Trp analog used to probe the allosteric properties of the internal aldimine of tryptophan synthas. Also shown to be a moderate inhibitor of tryptophan synthase, trypothan-2,3-dioxygenase, indoleamine-2,3-dioxygenase, L-dopachrome isomerase and xanthine oxidase. Reagent used as a matrix for MALDI-TOF mass spectroscopy in order to characterize and analyze polyphenols and synthetic polymers. Used as heterocyclic building block or intermediate for the synthesis of indolyl acrylamide-derived inhibitors, pharmaceuticals or agrochemicals. - Inflammation suppressor. Tryptophan metabolite produced by human microbiota (intestinal commensale Peptostreptococcus sp.). Involved in keeping the intestinal barrier intact and works as anti-inflammatory molecule. Patients with Inflammatory Bowel Disease (IBD) have an altered microbiota, with less Peptostreptococcus sp. and therefore reduced production of trans-indole-3-acrylic acid. Chromophoric L-Trp analog used to probe the allosteric properties of the internal aldimine of tryptophan synthase. Also shown to be a moderate inhibitor of tryptophan synthase, trypothan-2,3-dioxygenase (TDO), indoleamine-2,3-dioxygenase (IDO), L-dopachrome isomerase and xanthine oxidase. Reagent used as a matrix for MALDI-TOF mass spectroscopy in order to characterize and analyze polyphenols and synthetic polymers. Used as heterocyclic building block or intermediate for the synthesis of indolyl acrylamide-derived inhibitors, pharmaceuticals or agrochemicals.

O=C(/C=C/C1=CNC2=CC=CC=C21)O

2°C to 8°C

12352200