TRIM13 Antibody

Cusabio

TRIM13 Antibody

20

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

TRIM13

tripartite motif containing 13

B-cell chronic lymphocytic leukemia tumor suppressor Leu5; CAR; CLL-associated RING finger; DLEU5; E3 ubiquitin-protein ligase TRIM13; LEU5; leukemia-associated protein 5; putative tumor suppressor RFP2; ret finger protein 2; RFP2; RING finger protein 77; RING-type E3 ubiquitin transferase TRIM13; RNF77; tripartite motif protein 13; tripartite motif-containing protein 13

Rabbit

IgG

E3 ubiquitin-protein ligase TRIM13

E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor.

Human

-20°C or -80°C

12352203