TRIM25 Antibody, Biotin conjugated

Cusabio

TRIM25 Antibody, Biotin conjugated

20

ELISA

Research Use Only

Polyclonal

Biotin

Liquid

TRIM25

tripartite motif containing 25

E3 ubiquitin/ISG15 ligase TRIM25; EFP; estrogen-responsive finger protein; RING finger protein 147; RING-type E3 ubiquitin transferase TRIM25; RNF147; tripartite motif protein TRIM25; tripartite motif-containing protein 25; ubiquitin/ISG15-conjugating enzyme TRIM25; Z147; zinc finger protein 147 (estrogen-responsive finger protein); zinc finger protein-147; ZNF147

Rabbit

IgG

E3 ubiquitin/ISG15 ligase TRIM25

Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates \Lys-63\-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784).

Human

-20°C or -80°C

12352203