TRIM30 antibody

GeneTex

TRIM30 antibody

9

This antibody is specific for TRIM30 C-Terminus

WB: 1 microg/mL. IHC-P: 10 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

1 mg/ml

Liquid

Trim30a

tripartite motif-containing 30A

down regulatory protein of interleukin-2 receptor; regulatory protein, T lymphocyte 1; Rp; Rpt; Rpt1; Rpt-1; Trim; Trim30; tripartite motif protein 30; tripartite motif-containing 30; tripartite motif-containing protein 30; tripartite motif-containing protein 30A

Tripartite motif-containing protein 30A

TRIM30 belongs to a family of the tripartite motif (TRIM) proteins involved in the regulation of cell proliferation, differentiation, development, oncogenesis, apoptosis and antiviral responses. The TRIM protein family is an expanding family of RING (really interesting new gene) proteins, also known as RBCC proteins as they contain an RBCC motif, which comprises a RING domain, one or two B-boxes and a predicted coiled-coil region. Studies have shown that some TRIM family members are critical to innate immunity; TRIM5, TRIM19 and TRIM25, for example, have been shown to restrict viral infection. A recent study shows that TRIM30 functions as a negative modulator of the TLR signaling pathway, by targeting TAB2 and TAB3, and contributes to the inhibition of TLR-mediated NFkappa-B activation. The importance of TRIM30 in the attenuation or termination of NFkappa-B activation suggests that targeting of TAB2 and TAB3 by TRIM30 alpha may be a mechanism for modulating many types of immune responses.

-20°C or -80°C,2°C to 8°C

12352203