TRIM33 antibody

Biorbyt

TRIM33 antibody

16

Western Blot

WB:1:1000-1:3000 WB

Research Use Only

Polyclonal

Unconjugated

TRIM33

tripartite motif containing 33

E3 ubiquitin-protein ligase TRIM33; ECTO; ectodermin homolog; protein Rfg7; PTC7; RET-fused gene 7 protein; RFG7; RING-type E3 ubiquitin transferase TRIM33; TF1G; TIF1G; TIF1GAMMA; TIF1-gamma; TIFGAMMA; transcriptional intermediary factor 1 gamma

Rabbit

E3 ubiquitin-protein ligase TRIM33

Rabbit polyclonal to TRIM33.Tripartite motif-containing protein 33 (TRIM33) is a nuclear protein localized in discrete nuclear dotsresembling nuclear bodies. TRIM33 acts as an E3 ubiquitin-protein ligase, and promotes SMAD4ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. TRIM33 mayact as a transcriptional repressor of the TGF-beta/BMP signaling cascade. It is thought that TRIM33can monoubiquitinate SMAD4, which hampers its ability to form a stable complex with activatedSMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. TRIM33 plays a role in thecontrol of cell proliferation. Defects in TRIM33 are a cause of thyroid papillary carcinoma (TPC).

Human, Mouse

-20°C

12352203