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Trimetrexate (isethionate)

HY-10373B
MedChem Express
Molecular Weight495.55
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Trimetrexate (isethionate)
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Molecular Formula
    C21H29N5O7S
  • Molecular Weight
    495.55
  • Scientific Description
    Trimetrexate (CI-898) isethionate is an antibiotic , also a potent and orally active dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC 50 values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate isethionate can also inhibit the growth of various cancer cells. Trimetrexate isethionate can be used for researching Pneumocystis carinii pneumonia (PCP) and cancer [1] [2] [3] [4] [5] .
  • SMILES
    OCCS(=O)(O)=O.NC1=NC(N)=C2C(C)=C(CNC3=CC(OC)=C(OC)C(OC)=C3)C=CC2=N1
  • UNSPSC
    12352200