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Trimetrexate (trihydrochloride)

HY-10373A
MedChem Express
Molecular Weight478.80
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Trimetrexate (trihydrochloride)
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Molecular Formula
    C19H26Cl3N5O3
  • Molecular Weight
    478.80
  • Scientific Description
    Trimetrexate (CI-898) trihydrochloride is an antibiotic , also a potent and orally active dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC 50 values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate trihydrochloride can also inhibit the growth of various cancer cells. Trimetrexate trihydrochloride can be used for researching Pneumocystis carinii pneumonia (PCP) and cancer [1] [2] [3] [4] [5] .
  • SMILES
    NC1=C(C(C)=C2CNC3=CC(OC)=C(OC)C(OC)=C3)C(C=C2)=NC(N)=N1.[H]Cl.[H]Cl.[H]Cl
  • UNSPSC
    12352200