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Chemical Structure
Chemical Structure
Chemical Structure

Triptolide [38748-32-2]

Research Use Only
AG-CN2-0448
AdipoGen Life Sciences
CAS Number38748-32-2
Product group Chemicals
Estimated Purity>98%
Molecular Weight360.4
Price on request
Packing Size
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Triptolide [38748-32-2]
  • Delivery Days Customer
    10
  • CAS Number
    38748-32-2
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Non-hazardous
  • Molecular Formula
    C20H24O6
  • Molecular Weight
    360.4
  • Scientific Description
    Chemical. CAS: 38748-32-2. Formula: C20H24O6. MW: 360.4. Isolated from Tripterygium sp. Potent immunosuppressant with anti-inflammatory and antitumor properties. Exhibits potent antiproliferative activity, induces apoptosis, modulates autophagy and inhibits cell cycle regulators. Inhibits global gene transcription by inducing degradation of RNA polymerase II (Pol II) and by inhibiting the ATPase activity of XPB (a subunit of the general transcription factor TFIIH). Human dCTP pyrophosphatase 1 inhibitor. Interferes with a number of transcription factors including p53, NF-kappaB, nuclear factor of activated T cells (NFAT) and heat shock factor protein 1 (HSF-1). Shown to inhibit aromatase activity. Shows antifertility activity and antipolycystic kidney disease effects. - Potent immunosuppressant with anti-inflammatory and antitumor properties. Exhibits potent antiproliferative activity, induces apoptosis, modulates autophagy and inhibits cell cycle regulators. Inhibits global gene transcription by inducing degradation of RNA polymerase II (Pol II) and by inhibiting the ATPase activity of XPB (a subunit of the general transcription factor TFIIH). Human dCTP pyrophosphatase 1 inhibitor. Interferes with a number of transcription factors including p53, NF-kappaB, nuclear factor of activated T cells (NFAT) and heat shock factor protein 1 (HSF-1). Shown to inhibit aromatase activity. Shows antifertility activity and antipolycystic kidney disease effects.
  • SMILES
    CC(C)[C@]12O[C@H]1[C@@H]1O[C@]11[C@]3(O[C@H]3CC3C4=C(CC[C@]13C)C(=O)OC4)[C@@H]2O
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii: S.M. Kupchan, et al.; JACS 94, 7194 (1972)
  • Triptolide: a potential male contraceptive: Y. Lue, et al.; J. Androl. 19, 479 (1998)
  • Triptolide induces apoptotic death of T lymphocyte: Y. Yang, et al.; Immunopharmacology 40, 139 (1998)
  • Triptolide: a potent inhibitor of NF-kappa B in T-lymphocytes: H. Liu, et al.; Acta Pharmacol. Sin. 21, 782 (2000)
  • Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F: B.J. Chen; Leuk. Lymphoma 42, 253 (2001) (Review)
  • Triptolide inhibits the growth and metastasis of solid tumors: S. Yang, et al.; Mol. Cancer Ther. 2, 65 (2003)
  • Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death: S.D. Westerheide, et al.; J. Biol. Chem. 281, 9616 (2006)
  • Triptolide alters mitochondrial functions: Y. Su, et al.; Adv. Exp. Med. Biol. 599, 139 (2007)
  • Triptolide functions as a potent angiogenesis inhibitor: M.F. He, et al.; Int. J. Cancer 126, 266 (2010)
  • Triptolide inhibits proliferation and migration of colon cancer cells by inhibition of cell cycle regulators and cytokine receptors: S.M. Johnson, et al.; J. Surg. Res. 168, 197 (2011)