TRPC6-PAM-C20 [667427-75-0]

MedChem Express

TRPC6-PAM-C20 [667427-75-0]

10

667427-75-0

Research Use Only

99.78

C22H21NO4

363.41

TRPC6-PAM-C20 is a selective positive allosteric modulator (PAM) of TRPC6 channels. TRPC6-PAM-C20 is a potent enhancer of channel activation, enabling low basal concentrations of DAG to induce activation of the ion channel. TRPC6-PAM-C20 induces increases in intracellular Ca2+ concentrations ([Ca2+]i) in TRPC6-expressing HEK293 cells with an EC50 of 2.37 microM. TRPC6-PAM-C20 can be used as a valuable tool to selectively exaggerate TRPC6-dependent signals[1].

O=C1C(C2=NC(C)(C)CC3=C2C=C(OC)C(OC)=C3)=CC4=CC=CC=C4O1

-20°C,2°C to 8°C

12131703