TRV-120027 (TFA)

MedChem Express

TRV-120027 (TFA)

9

Research Use Only

99.69

TRV120027 TFA, a beta-arrestin-1 -biased agonist of the angiotensin II receptor type 1 (AT1R) , engages ?-arrestins while blocking G-protein signaling [1] . TRV120027?TFA induces?acute?catecholamine?secretion?through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R-beta-arrestin-1-TRPC3-PLCgamma at the plasma membrane. TRV120027 TFA inhibits angiotensin II-mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 TFA has the potential for the?acute decompensated heart failure (ADHF) treatment [2] .

-20°C,-80°C

12352202