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TSC2 antibody

Research Use Only
ORB106932
Biorbyt
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetTSC2

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Overview

  • Supplier
    Biorbyt
  • Product Name
    TSC2 antibody
  • Delivery Days Customer
    16
  • Applications
    Western Blot
  • Applications Supplier
    WB: 1:1000 WB
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Clone ID
    RB42286
  • Conjugate
    Unconjugated
  • Gene ID7249
  • Target name
    TSC2
  • Target description
    TSC complex subunit 2
  • Target synonyms
    LAM; PPP1R160; protein phosphatase 1, regulatory subunit 160; TSC4; tuberin; tuberous sclerosis 2 protein
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP49815
  • Protein Name
    Tuberin
  • Scientific Description
    Rabbit polyclonal to TSC2. In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors.
  • Reactivity
    Human, Mouse, Rat
  • UNSPSC
    12352203