TSEN54 Antibody

Cusabio

TSEN54 Antibody

20

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

TSEN54

tRNA splicing endonuclease subunit 54

hsSen54; PCH2A; PCH4; PCH5; sen54; SEN54 homolog; SEN54L; tRNA-intron endonuclease Sen54; tRNA-splicing endonuclease subunit Sen54; TSEN54 tRNA splicing endonuclease subunit

Rabbit

IgG

tRNA-splicing endonuclease subunit Sen54

Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5 and 3 splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2,3 cyclic phosphate and 5-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Zody M.C., Nature 440:1045-1049(2006). Paushkin S.V., Cell 117:311-321(2004). Ota T., Nat. Genet. 36:40-45(2004).

Human

-20°C or -80°C

12352203