TSH-Receptor, B-Chain (Thyroid Marker) (TSHRB/1404), CF640R conjugate, 0.1mg/mL [26628-22-8]

Biotium

TSH-Receptor, B-Chain (Thyroid Marker) (TSHRB/1404), CF640R conjugate, 0.1mg/mL

9

Research Use Only

Monoclonal

TSHRB/1404

0.1 mg/ml

Other Conjugate

TSHR

thyroid stimulating hormone receptor

CHNG1; hTSHR-I; LGR3; seven transmembrane helix receptor; thyrotropin receptor; thyrotropin receptor-I, hTSHR-I; TSH receptor

Mouse

IgG1

Thyrotropin receptor

Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Graves disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

Bovine, Human, Mouse

2°C to 8°C

12352203