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IHC-P analysis of mouse brain tissue using GTX85059 TSLP antibody. Working concentration : 2.5 microg/ml

TSLP antibody

GTX85059

ApplicationsImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

ReactivityHuman, Mouse

TargetTSLP

Overview

Supplier
GeneTex
Product Name
TSLP antibody
Delivery Days Customer
9
Application Supplier Note
WB: 0.5 - 2 microg/mL. IHC-P: 2.5 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID85480
Target name
TSLP
Target description
thymic stromal lymphopoietin
Target synonyms
thymic stromal lymphopoietin, thymic stroma-derived lymphopoietin
Host
Rabbit
Isotype
IgG
Protein IDQ969D9
Protein Name
Thymic stromal lymphopoietin
Scientific Description
Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. TSLP is a four-helix-bundle cytokine that is expressed mainly by barrier epithelial cells and is a potent activator of several cell types such as myeloid dendritic cells. TSLP is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Amino acid sequence analysis has shown poor homology between human and mouse TSLP although they exhibit similar biological functions and are expressed in similar tissues. Despite its predicted molecular weight, TSLP often migrates at a higher molecular weight in SDS-PAGE. At least two differentially spliced isoforms of TSLP are known to exist.
Reactivity
Human, Mouse
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

References

García LN, Leimgruber C, Nicola JP, et al. Neonatal endotoxin stimulation is associated with a long-term bronchiolar epithelial expression of innate immune and anti-allergic markers that attenuates the allergic response. PLoS One. 2020,15(5):e0226233. doi: 10.1371/journal.pone.0226233
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Qin W, Duan J, Xie X, et al. Exposure to diisononyl phthalate promotes atopic march by activating of NF-κB and p38 MAPK. Toxicol Appl Pharmacol. 2020,395:114981. doi: 10.1016/j.taap.2020.114981
Read this paper
Kao JK, Hsu TF, Lee MS, et al. Subcutaneous injection of recombinant heat shock protein 70 ameliorates atopic dermatitis skin lesions in a mouse model. Kaohsiung J Med Sci. 2020,36(3):186-195. doi: 10.1002/kjm2.12163
Read this paper
Wang E, Liu X, Tu W, et al. Benzo(a)pyrene facilitates dermatophagoides group 1 (Der f 1)-induced epithelial cytokine release through aryl hydrocarbon receptor in asthma. Allergy. 2019,74(9):1675-1690. doi: 10.1111/all.13784
Read this paper
Kang J, Duan J, Song J, et al. Exposure to a combination of formaldehyde and DINP aggravated asthma-like pathology through oxidative stress and NF-κB activation. Toxicology. 2018,404-405:49-58. doi: 10.1016/j.tox.2018.05.006
Read this paper
Shen S, Li J, You H, et al. Oral exposure to diisodecyl phthalate aggravates allergic dermatitis by oxidative stress and enhancement of thymic stromal lymphopoietin. Food Chem Toxicol. 2017,99:60-69. doi: 10.1016/j.fct.2016.11.016
Read this paper
Wilson SR, Thé L, Batia LM, et al. The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch. Cell. 2013,155(2):285-95. doi: 10.1016/j.cell.2013.08.057
Read this paper

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TSLP antibody

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