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ProductsBack/TSPAN12 Antibody, FITC conjugated

TSPAN12 Antibody, FITC conjugated

CSB-PA025149LC01HU
Cusabio
ReactivityHuman
Product group Antibodies
TargetTSPAN12
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Overview

  • Supplier
    Cusabio
  • Product Name
    TSPAN12 Antibody, FITC conjugated
  • Delivery Days Customer
    20
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    FITC
  • Gene ID23554
  • Target name
    TSPAN12
  • Target description
    tetraspanin 12
  • Target synonyms
    EVR5; NET2; NET-2; tetraspan NET-2; tetraspanin-12; TM4SF12; transmembrane 4 superfamily member 12; tspan-12
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDO95859
  • Protein Name
    Tetraspanin-12
  • Scientific Description
    Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity.
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203