Tubulin/HDAC-IN-4

MedChem Express

Tubulin/HDAC-IN-4

5

Research Use Only

C24H26N2O6

438.47

Tubulin/HDAC-IN-4 (compound 9n) is a dual Tubulin and HDAC inhibitor with IC50 values of 0.73, 0.43, 0.62, 2.34 microM for HDAC1, HDAC2, HDAC6, HDAC7, respectively. Tubulin/HDAC-IN-4 inhibits the tubulin polymerization by targeting the colchicine binding site. Tubulin/HDAC-IN-4 induces apoptosis and cell cycle arrest at G2/M phase. Tubulin/HDAC-IN-4 induces a significant elevation of intracellular ROS levels. Tubulin/HDAC-IN-4 shows anti-angiogenesis activity and anticancer activity[1].

CC1(C)OC2=C(C(/C=C/C3=CC=C(OC)C(NCC(NO)=O)=C3)=O)C=CC(OC)=C2C=C1

12352200