Tubulysin H

MedChem Express

Tubulysin H [799822-09-6]

10

799822-09-6

Research Use Only

C40H59N5O9S

785.99

Tubulysin H is a highly cytotoxic anti-microtubule toxin ( anti-microtubule toxins ) that is synthesized as an ADC cytotoxin ( ADC Cytotoxin ). Tubulysin H can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis . Tubulysin H displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC 50 values in the low nanomolar range. Tubulysin H inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis [1] [2] [3] .

O=C(N[C@@H]([C@@H](C)CC)C(N(COC(C)=O)[C@@H](C(C)C)C[C@@H](OC(C)=O)C1=NC(C(N[C@@H](CC2=CC=CC=C2)C[C@H](C)C(O)=O)=O)=CS1)=O)[C@@H]3N(C)CCCC3

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