Tuspetinib hydrate [2758339-04-5]

TargetMol Chemicals

Tuspetinib hydrate [2758339-04-5]

16

Research Use Only

C29H35ClN6O

519.08

Tuspetinib (HM43239) hydrate is a selectively active FLT3 inhibitor for oral administration, demonstrating IC50 values of 1.1 nM for FLT3 WT, 1.8 nM for FLT3 internal tandem duplication (ITD), and 1.0 nM for FLT3 D835Y kinases. As a reversible type I inhibitor, it suppresses FLT3 kinase activity and influences signaling pathways including p-STAT5, p-ERK, SYK, JAK1/2, and TAK1. Additionally, Tuspetinib hydrate inhibits leukemic cell proliferation and triggers apoptosis [1] [2] [3].

ClC=1C(C=2C=3C(NC2)=CC(C)=CC3)=NC(NC4=CC(=CC(CN5C[C@@H](C)N[C@@H](C)C5)=C4)C6CC6)=NC1.O

-20°C

12352200