TUT1 Antibody

Cusabio

TUT1 Antibody

20

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

TUT1

terminal uridylyl transferase 1, U6 snRNA-specific

nuclear speckle targeted phosphatidylinositol 4-phosphate 5-kinase type I-alpha regulated-poly(A) polymerase; nuclear speckle-targeted PIPK1A-regulated-poly(A) polymerase; PAP-associated domain-containing 2; PAPD2; poly(A) polymerase associated domain containing 2; RBM21; RNA uridylyltransferase; RNA-binding motif protein 21; RNA-binding protein 21; speckle targeted PIP5K1A-regulated poly(A) polymerase; STARPAP; star-PAP; TENT1; TUTase; TUTase 6; U6 snRNA-specific terminal uridylyltransferase 1; U6-TUTase; up-regulated in lung cancer 6; URLC6

Rabbit

IgG

Speckle targeted PIP5K1A-regulated poly(A) polymerase

Poly(A) polymerase that creates the 3-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3-end cleavage of pre-mRNAs: binds to the 3UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation. Ota T., Nat. Genet. 36:40-45(2004). The MGC Project Team, Genome Res. 14:2121-2127(2004). Trippe R.,RNA 12:1494-1504(2006).

Human

-20°C or -80°C

12352203