Tuxobertinib [2414572-47-5]

MedChem Express

Tuxobertinib [2414572-47-5]

10

2414572-47-5

Research Use Only

99.69

C29H29ClN6O4

561.03

Tuxobertinib (BDTX-189) is a potent, orally active and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations, including EGFR/HER2 exon 20 insertion mutants. Tuxobertinib shows KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively. Anticancer activity[1].

C=CC(NC1=CC2=C(NC3=CC=C(OCC4=NC=CC=C4)C(Cl)=C3)N=CN=C2C=C1OCCN5CCOCC5)=O

-20°C,2°C to 8°C

12131703