TW9

TargetMol Chemicals

TW9

999

Chemical

Research Use Only

TW9

TW9 is a dual inhibitor of bromodomain 2 (BD2) in bromodomain-containing protein 4 (BRD4) and histone deacetylase 1 (HDAC1; IC50s = 0.074 and 0.29 microM, respectively).1It is selective for BD2 over BD1 in BRD4 (IC50= 0.72 microM) and for HDAC1 over HDAC2 (IC50= 2.5 microM). TW9 (50 nM) induces apoptosis in, and inhibits proliferation of, MIA PaCa-2 pancreatic cancer cells. It induces cell cycle arrest at the G1phase in HPAC pancreatic cancer cells when used at a concentration of 2 microM. TW9 acts synergistically with gemcitabine to reduce the viability of HPAC cells.

3 years

-20°C

12352200